Remove face
Click the faces of a feature — a hole, a boss, a pocket — and press Enter. The feature is taken away and the neighbouring faces extend and meet each other.

Select all the faces of the feature: for a hole that is the cylinder (and the bottom, if it is blind), for a boss its side and top.
What it is for
Above all — to simplify someone else's geometry. A STEP file arrives with threads, tiny fillets and manufacturing holes, and all you need is the envelope for layout. It has no history and nothing to roll back: a detail can only be removed together with its faces.
The second use is taking away what should not be in the model: a hole for an old fastener, a pad from a previous revision.
When it will not work
If the neighbouring faces cannot be stretched to meet — deleting a face where half the part converges, say — the command refuses: there is nothing to close such a gap with.
Then remove one face at a time, starting with the smallest.